Isocyanate exposure and occupational asthma: a case-referent study

Isocyanate exposure and occupational asthma: a case-referent study.

OBJECTIVE To examine the quantitative relation between exposure to isocyanates and occupational asthma, and to explore the role of atopy and smoking in occurrence of the disease. METHOD A case-referent study was undertaken of cases from two manufacturing companies (A and B) from which referents without disease could be selected and reliable exposure measurements were available. In company A, ...

Isocyanate exposure in bathtub refinishing: à propos a case of occupational asthma.

Work-related asthma in a bathtub refinishing technician prompted measurements of isocyanate exposure in this operation. Very high levels of hexamethylene diisocyanate (HDI) oligomer, up to 8500 microg/m3 NCO, were found during top varnish spray-painting, whereas the levels of HDI monomer were substantially lower. The results suggest that only full-piece, self-contained respirators would suffice...

Methodological problems in a case-referent study based on a register of occupational asthma.

Occupational exposure to hydrocarbons and chronic pancreatitis: a case-referent study.

OBJECTIVES To investigate the hypothesis that hydrocarbon exposure is a risk factor for chronic pancreatitis. METHODS 102 cases of chronic pancreatitis and 204 age and sex matched referents were interviewed about their occupational histories, alcohol and cigarette consumption, and diet. Exposure to hydrocarbons was inferred from interview responses by four assessors who were blind to disease ...

Radiological irregular opacities and coalwork exposure: a case-referent study.

Five hundred and fifteen men newly attending chest clinics in coalmining areas of England and Wales were entered into a study of the risk of irregular opacities on the chest radiograph in relation to occupation; readable radiographs were received for 489. The men completed questionnaires on occupational and smoking history and the radiographs were read for irregular opacities by the collaborati...